Associate Scientist – Next-Generation Sequencing (NGS)

SeqMatic is a Next Generation Sequencing (NGS) and omics services provider based in the San Francisco South Bay Area. The company was founded in 2012 by former Illumina R&D scientists who are experts in the NGS workflow and related bioinformatics.

We specialize in Illumina NGS platforms, bulk DNA/RNA-seq, Single-cell RNA, as well as custom sequencing services with fast turnaround times. Our lab is CLIA / CAP certified. We recently expanded our capabilities beyond RUO to support clinical trials for our Clients, in addition to incorporating novel technologies such as Spatial Transcriptomics, Epigenetics, Proteomics and Histopathology.

**Role Overview**

We are looking for a detail-oriented and hands-on Scientist to support and expand our Next-Generation Sequencing (NGS) operations. This role will be instrumental in onboarding new services, developing and optimizing workflows, and supporting day-to-day NGS laboratory activities, particularly in library preparation.

The ideal candidate is highly organized, technically strong in NGS methods, and excited to drive process improvements in a dynamic lab environment.

**Key Responsibilities**

• Lead the onboarding of new NGS service offerings, including workflow design, validation, and implementation
• Develop, optimize, and troubleshoot NGS library preparation protocols across multiple platforms and applications
• Execute daily NGS lab operations, ensuring consistency, accuracy, and high-quality outputs
• Evaluate and improve existing workflows to enhance efficiency, scalability, and turnaround time
• Collaborate cross-functionally with bioinformatics, operations, and quality teams to ensure seamless service delivery
• Document SOPs, validation reports, and process updates in compliance with quality standards
• Train and mentor lab staff on new workflows and best practices

**Qualifications**

**Required:**

• Master’s or Doctorate degree in Molecular Biology, Genomics, Biotechnology, or related field
• 5+ years of hands-on experience in an NGS laboratory environment
• Strong expertise in NGS library preparation techniques (e.g., WGS, RNA-seq, targeted panels, etc.)
• Experience in workflow optimization, assay development, or process improvement
• Familiarity with sequencing platforms (e.g., Illumina, PacBio, Oxford Nanopore)
• Strong attention to detail, analytical thinking, and troubleshooting skills
• Excellent documentation and communication abilities

**Preferred:**

• Experience on-boarding new assays or services in a clinical or commercial lab setting
• Knowledge of quality systems (CLIA, CAP, GLP, or similar)
• Exposure to automation platforms for library preparation
• Basic understanding of NGS bioinformatic analysis workflows